On the other hand spending a day casually driving back roads is kind of fun, and you’re going to spend time traveling either way so more reasonable road trips still exist.
When I'm at work my company paid for flights, but even then many will tell you if it is only 12 hours to drive, just rent a car: flying is a headache and doesn't really save enough time to be worth it. (if you are going to/from a major hub then flying is great, but we often go between minor cities, which means several hours at various airports)
So for me it’s generally fly to whatever the closest major airport is then rent a car and drive the last leg. That shaves most of the driving and avoids layovers etc while adding 3-4 hours for the flight + airport.
I can see you driving up to say 15h, but even then for a 20+ hour drive you might as well drive to a major airport fly and then drive the last leg.
Some will do 30+ hours straight, only stopping when they get gas. That is your baldder better make it to the next gas station and once there you need to not only use the restroom, but also find whatever you are going to eat - when the gas tank is full the car leaves. This is not safe, but it is done often.
Time to add 100 miles is probably the best gauge of road trips. That is a good number to stop at for a break (cars are 200-300 - but this is too long). 15-20 minutes every 100 miles is a good amount of time to force someone to walk around to charge - this time is about health. However if your times to much above that people have places to be and EVs are getting in the way. (I'm assuming that charging infrastructure supports that - it isn't quite there everywhere but that is coming fast)
Car are cheap once you have one (most of the costs are fixed so even if it sits in the driveway you still pay the cost), and so where I live in the mid west long road trips like the above are common - flying ends up being very expensive and doesn't save a lot of time at best, and at worst you miss a transfer and end up someplace you don't want to be for a few days. Trains are in theory possible, but also expensive and doesn't run great schedules.