Mid-old cells are a potential target for anti-aging interventions in the elderly

Re:Mid-old cells are a potential target for anti-aging inter... by graphe on Friday November 24, 2023 @05:11AM (#38402325)

Don't your telomeres get shorter, your DNA gets damaged and it doesn't replicate correctly anymore? Some animals can be immortal like lobsters but face limits like their physical size can kill them when they molt enough.

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Re:Mid-old cells are a potential target for anti-aging inter... by tambourine_man on Friday November 24, 2023 @07:14AM (#38403181)

I think the consensus is that it’s part of the process, but not the whole picture, but I’m no expert.

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Re:Mid-old cells are a potential target for anti-aging inter... by throwaway60703 on Friday November 24, 2023 @08:20AM (#38403697)

Yes, that's one of around 50 currently recognized factors of aging.

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Re:Mid-old cells are a potential target for anti-aging inter... by echelon on Friday November 24, 2023 @10:56AM (#38405188)

https://en.wikipedia.org/wiki/Hallmarks_of_aging

This isn't comprehensive, though. I don't see intracellular or extracellular waste accumulation, for instance.

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Re:Mid-old cells are a potential target for anti-aging inter... by calepayson on Friday November 24, 2023 @01:00PM (#38406494)

I'm not sure if this is one of the consensus primary causes but the most compelling explanation I've heard is capillary damage.

Red blood cells and capillaries have roughly the same diameter leading to constant friction. Your body repairs the capillaries but, given enough time, it makes mistakes. As these mistakes pile up your circulatory system, your body's supply chain, slowly gets less efficient. This leads to every cell in your body gets the energy it needs a little later, and has to hold onto waste for a little longer.

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Re:Mid-old cells are a potential target for anti-aging inter... by BobaFloutist on Friday November 24, 2023 @05:03PM (#38408891)

If aging was just DNA errors, wouldn't it be far less consistent in how it effected people?

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