Human and computer hardware are not comparable, after all even with the latest chips the computer is just (many) von Neumann machine(s) operating on a very big (shared) tape. To model the human brain in such a machine would require the human brain to be discretizable, which, given its essentially biochemical nature, is not possible - certainly not by 2029.

It depends on the resolution of discretization required. Kurzweil's prediction is premised on his opinion of this.

Note that engineering fluid simulation (cfd) makes these choices in discretization of pde's all the time, based on application requirements.