The evidence on higher tobacco and alcohol taxes, for instance, is pretty irrefutable.
Or, moving up the implausibility scale in the American context, drastic reductions in the availability of handguns including the mass forfeiture of existing weapons (which has been done in a number of other developed countries).
You may not like any of these, particularly the last, but the fact is that they would increase life expectancy significantly.
The audience and context was the colony of Pennsylvania deciding to accept an offer from the Penn family to provide a one-off detachment of mercenaries to patrol the colony's western border in exchange for a perpetual ban on taxing the Penn landholdings.
The safety was border defense. The liberty was the colonial government's authority to pass law. In context, Franklin is saying "The government that cedes its taxation authority over the citizens for a temporary boon from its richest citizens deserves neither the boon nor the authority."
https://www.getsmartaboutdrugs.gov/media/dea-administrator-r...
That is a sad situation, but giving up more liberty won't save those people. Freedom is more important than safety and I have no interest in living under an authoritarian police state.