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A comment on Nicotine: On the benefits and lack of demerits of nicotine. Parent comment

Re:Nicotine: On the benefits and lack of demerits of nicotine by kallistisoft on Saturday November 11, 2023 @05:03PM (#38235024)
Tobacco contains Harmaline which is an MAOI - it both increases the bioavailability of nicotine as well as adding an additional psychoactive effect; stimulant + anti-depressant

I've recently started adding free base harmaline to my vape juice to create a proper tobacco substitute... I found that nicotine alone didn't provide the relaxation that I would get from smoking tobacco. After a fair amount of research I discovered that it was that lack of harmala compounds.

https://en.wikipedia.org/wiki/Harmala_alkaloid

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Re:Nicotine: On the benefits and lack of demerits of nicotine by friend_and_foe on Sunday November 12, 2023 @06:51PM (#38245378)
Well, I'm past that addiction now so I don't want to try it to stir it up, but I've had pipe tobacco and cigar tobacco, as well as chewing tobacco since I quit cigarettes and I've never had them rope me back in even a little bit. So I think cigarettes have something else going on. Maybe I'm wrong.

I am curious though if this worked for you as a full substitute to sate cravings, and what amount you added.

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