Wow that's insane. Any examples in particular? I knew about some plant seeds that if eaten raw have toxins like canavanine that cause malformed proteins but wouldn't be obvious at first or (afaik) if you still overwhelmingly had enough protein in your diet... but getting your DNA completely shredded like that from a source other than radiation sounds so intense.

Destroying Angel and similar mushroom's have a toxin in it which kills some kind of rna enzyme needed for cell's to function properly. Not sure if it exactly fits the bill of DNA shredding but it'll give you irreversible organ failure in a matter of hours

https://en.wikipedia.org/wiki/Destroying_angel

Yeah, I think this kind of procedure is basically for "you're stuck in the wild, and if you don't find something to eat soonish, you're dead anyway".

So it's inherently risky, not sure there _is_ a non-risky way out. But you definitely wouldn't want to do this without need.

This happened on Naked and Afraid where some guy found chicken mushrooms but didn’t boil them before eating them and almost died of liver failure.