What Lisp do you have in mind? Presumably you mean something more specific by "goes straight to asm" than just "is compiled".

If I were going to do this I would build a Lisp bottom-up from the instruction set and my goal would be to find the most interesting language could emerge that way. On the other hand, that's so similar to what Forth already does that it might be better just to treat the hardware as the Forth machine it already is and do what it wants.

You'd take the Richard Gabriel approach, in which you do all kinds of tricks by playing around with macros and types.

Of course you'd probably run it in X86 and let that compile to a binary you propagate through your supercomputer.