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Re:Study shows antibodies against PEG in 83% of the German p... by Enginerrrd on Friday October 27, 2023 @10:26AM (#38038883)
Diet and exercise absolutely does work. It's just that when you frame the intervention as TELLING people to eat less and exercise more, it is very ineffective. So from a physician's standpoint, it's not a great approach.
Re:Study shows antibodies against PEG in 83% of the German p... by kragen on Friday October 27, 2023 @10:37AM (#38039034)
it's almost as ineffective when undertaken on your own initiative; that's where the 95% number comes from

diet and exercise is clearly the proximate cause of obesity, but the question is what drives diet and exercise, and what changed so suddenly?

Re:Study shows antibodies against PEG in 83% of the German p... by Pigalowda on Friday October 27, 2023 @10:53AM (#38039269)
Education and socioeconomic status correlate with lower obesity rates, healthy diet, and exercise.

The “sudden” change is easy to see in the supermarket. Most people don’t shop at Whole Foods, Sprouts, or Central market. Go to Walmart and admire all of the densely caloric colorful boxed foods.

Did you know young people actually use door dash/uber to get their fast food? It’s wild. So not even expending a few calories to get it but also wasting a bunch of cash.

Re:Study shows antibodies against PEG in 83% of the German p... by galangalalgol on Friday October 27, 2023 @11:23AM (#38039692)
Stress is a leading cause of inflammation. Financial insecurity causes stress and lack of free time to exercise or prepare meals. Hard to separate the variables.

The drive to eat and what is strongly influenced by gut biome. Fecal transplants have created new food preferences.

Even saying diet and exercise are the proximate cause may be an oversimplication. We know that the same level of activity and food intake can produce different results in different people. That doesn't violate thermodynamics. There are caloric expenditures that are not measured in such studies, like incomplete digestion and thermal regulation.

People shouldn't eat what they are eating, and they should have alternatives that are healthy for them (which also varies by person, but is almost never equal parts transfat and fructose with a petroleum based dye to make it pretty and to cut the sweetness, enough salt to cure a whole pig).

Re:Study shows antibodies against PEG in 83% of the German p... by vgatherps on Friday October 27, 2023 @10:42AM (#38039102)
Beyond the fact that just telling people to do so is ineffective, my experience is that most people have a very poor idea of what is and isn't calorie dense (I've been there!), how many calories they consume in snacks, or how to eat in a way that leave you feeling full without gobbling down calories.

I've been around people who made legitimate good-faith efforts to diet and eat "healthy", but have no idea that "just a bowl of rice to go with it" and "I need my afternoon milk tea" and maybe another snack are like 500+ extra calories each day, that hardly even leave you full.