We've had thousands of years experience with psilocybin. We've already synthesized more potent psychedelics for 75ish years. I'd argue that the safety is well understood, but of course effective dosage in clinical trial are not. However, there's plenty of information from psychonauts out there on how to consume shrooms safely.

But neither of these chemicals are magic. A lot of people are looking for magic pills. A lot of companies want to sell you magic pills. Take a couple pills and your problems go away; that's just not achievable anytime soon. We have to get better as a Western society of supporting people on their various, multifaceted journeys through life.