I'm subscribed to ~25 podcasts but wouldn't recommend most of them... which I guess means it's time for me to clean up my list. Here are some that I would recommend:

Non-tech (in order of awesomeness): 30 Seconds with Phone Guy; WNYC's Radio Lab; This American Life; On Point with Tom Ashbrook; CBC Radio 3 Podcast; A Prairie Home Companion's News from Lake Wobegon;

Tech (NOT in any order): MacBreak Weekly; This Week in Tech (TWiT); Freelancing on Rails; Ruby on Rails Podcast; Hivelogic Radio