'Remarkable' medical discovery for sepsis moves to next phase of human trials

Re:'Remarkable' medical discovery for sepsis moves to next p... by DoreenMichele on Friday October 13, 2023 @07:18PM (#37876666)

B vitamins are water soluble, so they are generally relatively safe to take in large amounts because they don't accumulate in the body, so you can't poison yourself like you can with some things. Some water soluble vitamins are associated with kidney stones if taken in high doses, so "unlikely to poison yourself" does not mean zero side effects.

I am seeing conflicting reports on B1 aka thiamine. If you don't have a compelling reason to try megadoses, I wouldn't do it. There's a lot we don't know.

But for many things, it's completely reasonable to increase your consumption of B vitamins. There's a lot of space between do nothing and megadoses that is safer to play in than skipping straight to megadoses.

/not a physician and don't play one on TV.

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Re:'Remarkable' medical discovery for sepsis moves to next p... by et2o on Friday October 13, 2023 @08:36PM (#37877067)

This is a simplification. For example niacin (vitamin B3) excesses cause cholesterol to become more atherogenic. And supplementation in patients without deficiency is ultimately harmful.

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Re:'Remarkable' medical discovery for sepsis moves to next p... by xiljin on Friday October 13, 2023 @08:59PM (#37877175)

Megadosing B6 can lead to B6 toxicity/syndrome as a result of its longer half life and ability to accumulate in the system. Between multivitamins, energy drinks, preworkouts and food, it's very easy to go well above the recommended amount. I'm currently recovering from B6 induced peripheral neuropathy (tingling in my feet) caused by 20-50mg/day over several years.

https://en.wikipedia.org/wiki/Megavitamin-B6_syndrome

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