'Remarkable' medical discovery for sepsis moves to next phase of human trials

Re:'Remarkable' medical discovery for sepsis moves to next p... by tuatoru on Friday October 13, 2023 @05:38PM (#37875900)

There is an "undernutrition" hypothesis.

Back in the day when we were all doing enough work (men, women, children) to need over twice our base-metabolic-rate number of calories per day, and eating whole foods, particularly red and white offal and leafy greens like collard and beet greens, steamed and roasted, we got enough of these mesonutrients and micronutrients.

Twice your BMR is about 5000 Cal/day for an adult male. You need to do eight hours' physical work (shoveling, threshing, chopping, sawing, lifting, doing the laundry by hand, etc.) to burn off the extra.

Now, the hypothesis says, we are deficient in many of these nutrients because we simply do not eat enough food, only 2500 Cal/day.

I have no investment in the hypothesis. Just reporting it.

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Re:'Remarkable' medical discovery for sepsis moves to next p... by andai on Friday October 13, 2023 @05:43PM (#37875950)

That is an interesting point. What we also know is that soils are being depleted of minerals, and farmers are selecting for crops with higher shelf life over higher nutrition.

e.g. tomatoes have lost most flavor and nutrition over past few decades, some efforts are underway to hybridize them with older variants to get the best of both worlds.

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Re:'Remarkable' medical discovery for sepsis moves to next p... by _a_a_a_ on Friday October 13, 2023 @07:06PM (#37876583)

> e.g. tomatoes have lost most flavor and nutrition over past few decades

can't speak for nutrition (nor do you provide support for that claim) but as to flavour, you clearly haven't been round long! Old fashioned tomatoes were shite I can testify (at least those available in the UK).

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Re:'Remarkable' medical discovery for sepsis moves to next p... by galangalalgol on Friday October 13, 2023 @07:19PM (#37876669)

My grandmother said the ones from the 20s in the us tasted way better, but they didn't keep any time at all, which was fine because they grew or raised all their own food.

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Re:'Remarkable' medical discovery for sepsis moves to next p... by serf on Friday October 13, 2023 @09:42PM (#37877411)

same story here. she also said that it was commonplace for people to have plants that originated from seeds from 'the old world' and brought over; maybe they were at that point closer to some genetic cousin.

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Re:'Remarkable' medical discovery for sepsis moves to next p... by wise0wl on Friday October 13, 2023 @08:17PM (#37876978)

I grow heirloom tomatoes in the United States, and they are spectacular. The tomatoes available in the grocery store pale in comparison to anything grown in your own garden.

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Re:'Remarkable' medical discovery for sepsis moves to next p... by briHass on Friday October 13, 2023 @08:58PM (#37877173)

This probably has more to do with the fact that supermarket tomatoes are picked before they fully ripen on the vine (often green). I also enjoy growing my own (Brandywine is a favorite), and letting it ripen on-vine to the point where it's probably hours away from falling off or starting to rot results in a much better tasting tomato than jumping the gun.

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Re:'Remarkable' medical discovery for sepsis moves to next p... by galangalalgol on Friday October 13, 2023 @07:17PM (#37876659)

Thanks for that, very interesting. There used to be some fruitarian who said his bloodwork was all perfect eating primarily some ridiculous number of bananas each day. And his conclusion everyone should just eat fruit. Well he was burning over 10000 calories a day bicycling, I think he was a delivery rider and it was his hobby. That diet doesn't scale down to 2000 calories for the reasons you mention. I also wonder about all that potassium...

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Re:'Remarkable' medical discovery for sepsis moves to next p... by polishdude20 on Friday October 13, 2023 @08:25PM (#37877010)

Do you have a source for the amount of calories we used to consume historically? Twice the calories means twice the food which means twice the bulk, twice the time to eat etc. My perception is that we were actually quite underfed historically.

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