People's brains just work differently. I don't remember "closing Awesome is Mod4 + Shift + the second key from the left on the bottom row", I remember "Mod4 + Shift + Q (for 'quit')" and my fingers know how to find 'Q'. If I change to Qwerty I'd have plenty of applications where the locations of keyboard shortcuts would change (like "Ctrl + C (for 'Copy')") and not having the keyboard shortcut for "close Awesome" change would be disorienting.

That said, maybe I'd have an easier time if it were possible to find a physical Dvorak keyboard, but alas: "worse is better".

OT: Wayfire is a really cool project and I admire how well it runs, it's real quality software.