When I was a teenager, I had a Windows machine I used for 3D animation and an iPod. I needed to charge the iPod and my mom was calling "dinner!" so I plugged it in quickly and ran off to eat.

When I came back, I realized the Windows machine had a cheap Firewire socket that didn't enforce the orientation. I had plugged in my iPod upsidedown.

I don't remember what it fried. I don't remember the iPod dying, so I'm guessing that socket never worked again.