No to mention, if you want a unique industrial design for your product to stand out then you are going to need custom tooling.
I do this for my personal projects (volume < 5) and the results are nice and functional. You can also cut holes for buttons and whatnot and you get something well tailored for your needs.
Laser cutting can be quite big and make a large volume box, if that's what you need. And transparent plexi is nice (if it fits your needs).
For small production runs, definitely. There are standard aluminum extrusions for boxes with PC boards. You slide the PC board in, and provide custom flat end plates with holes for connectors and controls. Here's one of mine.[1] The end plates were cut on a laser cutter. Here's a supplier in China.[2] For small boxes, the aluminum extrusion alone should cost a few dollars.
Somewhere above a few thousand, custom injection molding becomes cheaper. Amusingly, these are better boxes than plastic injection molding, but don't look like consumer products.
[1] https://github.com/John-Nagle/ttyloopdriver/raw/master/board...
[2] https://www.alibaba.com/product-detail/CHANGHE-electronics-a...
It seems everyone reinvents the plastic-rectangle-with-grooves. Is there some obvious reason for this?
And is there some canonical place you can get some proven high-quality boxes in bulk?
A friend and I made some sensor boards and used off the shelf waterproof enclosures - but I wonder if there is some go-to standard enclosures that people go for