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A comment on Pharmacokinetics: Drug Development's Broken Stair. Parent comment

Re:Pharmacokinetics: Drug Development's Broken Stair by opportune on Saturday September 30, 2023 @05:13PM (#37719867)
Warfarin is one of the most well known scientifically, but as a practitioner you may not know this because hospitals and insurers are scared to acknowledge the ongoing rate of preventable bad outcomes caused by not accounting for variances in metabolism.

That is to say, if we were to actually start assessing patients’ ability to metabolize warfarin we’d have to confront the fact that a huge number of bad clinical outcomes in the recent past stemmed from not doing this.

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Re:Pharmacokinetics: Drug Development's Broken Stair by carbocation on Saturday September 30, 2023 @05:20PM (#37719931)
> hospitals and insurers are scared to acknowledge the ongoing rate of preventable bad outcomes caused by not accounting for variances in metabolism.

Healthcare systems are so aware of and open about warfarin's risks that they have warfarin clinics set up to repeatedly measure patients' prothrombin times so that they can adjust dosing empirically. Further, they also provide nutritional guidance to patients taking warfarin to help them reduce diet-influenced variance in warfarin metabolism.

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