As I layman, I am more concerned that drastic alterations to the oral microbiome could have many negative downstream effects on health, from everything to digestion (naturally) to heard disease and neurodegenerative disorders. All of which show some correlation to an altered oral microbiome. We barely understand the connections, but that is obviously an argument in favor of caution.

I'm grateful that there are people out there willing to be guinea pigs for stuff like this, but I definitely wouldn't touch this kind of product until there are years (ideally decades) of usage with systemic scientific investigation into immediate complications as well as long term health impacts.