Even as recently as 2021, I still kept around a Windows partition for the occasional game that wouldn't run on Proton. I was still able to play the majority of what I wanted, but brand new titles often required patches after release, or some games would crash on occasion.

Now? I haven't even thought about compatibility in months. I don't even look at the user tweaks anymore, when it used to be a constant factor. Granted, I don't play multiplayer games with anticheat, which last I heard was still a lingering issue. Your mileage may vary, but I completely removed my Windows partition a while ago, and haven't even thought about since.