I had/have multiple Twitter IDs: one for me personally, one for a particular topic, and one for brands and even other for IoT experiments. One of the brand accounts was handed over along with other assets when company IPR was sold: it was a role account,
The first two I have replicated on Mastodon. I have stopped using all the Twitter accounts, so I have now 'slimmed down'.
To me it seems like the main question is the amount of friction encountered in switching accounts in clients. In more polished clients like Ivory this is just as easy as it is with Twitter.