I have CF and I was fortunate enough to qualify for Trikafta despite one of my protein mutations not responding to the drug. I have seen some great quality of life improvements from Trikafta like being able to go to the gym again, not being as winded climbing stairs, gaining weight, and having fewer lung infections.

However, Trikafta can't reverse the years of damage from CF, inflammation, and heavy antibiotics to combat nasty infections. I do experience some anxiety and mood swings and have developed recurring kidney stones since starting it.

Still, I am thankful that such a drug is available to me and many others like me. Maybe one day CFers will never understand what it means to have advanced lung disease.