Sure, maybe under a controlled environment where candidate selection is a thing. I've seen some wild reactions in people who turned out to have undiagnosed bipolar disorder or border line personality disorder at the time. They all got diagnosed and treated at a later date so hooray for them. But goddamn, the serotonin dump from even a moderate amount of mdma triggered some intense episodes of mania. Hell, I bet you could use it as a means of diagnosis; it was so obvious in retrospect. Group of friends, chill environment, everyone taking about the same amount, good quality stuff and one person just losing their shit afterwards. Makes you suspect there's something not quite right with them..