History will look unkindly upon people who kept these substances out of the hands of people who need them because "I knew a guy once who did too much street MDMA and went stupid."

Honestly, adopting that position in the face of a well-designed Phase 3 RCT showing such strong results is pretty much actively evil as far as I'm concerned. People are suffering. People are blowing their brains out after combat; people are afraid to get in their cars after accidents, or walk outside or have sex after being raped, and you're like "ehh Idk I knew a guy." Come on.

I would not take this every day for a month even if you offer me a years salary.

Every medic who thinks this is a good idea should do the self test in my opinion. The same goes for giving ritalin to kids, but that is a different story...

Why don't you just say folk wisdom? Commonly rumored? Calling something "knowledge" doesn't make it such. The entire point of science, and the reason it's so ridiculously hard, is that common knowledge is so frequently wrong.

> I would not take this every day for a month even if you offer me a years salary.

Then don't? No one is asking you to, nor is this trial nor the proposed line of treatment anything like this.

> Every medic who thinks this is a good idea should do the self test in my opinion.

I have a better proposal: how about they do a bunch of solid RCTs on it? That way we get actual information instead of noise.

You know the story of mdma? It was developed for medical use...

And I sayd im skeptical of this, because I cannot imagin, that any serious study, considering the risks comes to this conclusion. Unless it literally stops people from suicid. But as far as I know it's more probable to increase this risk so idk.

On the other hand, they dont factor in the body mass of the patient and give everyone the same dosage. That doesnt seem high quality to me. And 120-180mg isn't just a little. Thats at the upper end of what you would take when you go to a party, just for reference. Give this to someone with 60kg body mass and they can have a very bad experience.

Good but somehow a lot of medics give ritalin to kids. If you would buy some ritalin, and also some speed. Try both and realize it is pretty similiar.

I know someone in his mid twenties who has a tremor in his left hand because he had to take this since the age of 10.

And maybe there are cases where it makes sense. But defenitely not in that amount. Idgaf about what anyone tells me about this.

From the article:

The treatment period consisted of three 8-h dosing sessions, in conjunction with therapy, spaced approximately 1 month apart.

It's still a pretty heavy dosage. Most sane ravers would take less with more time in between. But I guess if you stop after 3 sessions it is ok.

They gave everyone the same dosage without considering the body mass.

Then 120mg as initial dosis for someone who has no tolerance is a crazy kick (considering body mass of ~80kg).

People don't really build tolerance to MDMA when they use it responsibly.

This is a phase 3 clinical trial, aka the last and most rigorous phase before potential FDA approval. There have already been studies previous to this one that establish safe bounds for dosage of chemically pure MDMA in a clinical setting, many of which are targeted at patients with "no tolerance" (aka drug naïve).

You are clutching pearls pretty hard here. Experimental medicine is not without risks. Apparently 8 whole active study group participants (less than 10%) experienced mild tachycardia, aka fast heartbeat, in a setting full of trained medical professionals with the skills and equipment to handle such events. There was also some sweating and nervousness. Compare that to a moderate to bad episode of PTSD and it's a walk in the park by comparison. This is highly ethical research. Take a breath and carefully read the full study and some of its references, as well as some other ones prior to this phase 3 trial, if you are seriously concerned about this issue.

300mg, especially for someone without prior MDMA experience, is an absolutely unhinged hero dose.

300mg spaced out over the course of 12 hours or so is somewhat less so, but you absolutely will get fewer effects on re-dosing, and fewer the next day as well if you dose again.

That said 120mg should be pretty safe for anyone, but with lower-tolerance or lighter users, could definitely reduce their ability to engage in meaningful conversation or retain any memory of what they discussed.

Which isn't to say they won't come away from the experience feeling warm fuzzies and possibly with significant improvements in their PTSD symptoms, but it does make me wonder if it's a good way to study how much of that is the talk therapy and how much is just the therapeutic effects of the drug

That a tesla pill with 0-300 mg can be harmful is obvious^^

The intended therapy is taken several times in a guided sessions, 3 for this study, with a therapist. They aren't just sending people home with a bottle of mdma to take before bed.

Resets are not a recurring situation. I'd take it as a sign of using the treatment in bad faith.

But one interesting thing to note:

> Least squares (LS) mean change in CAPS-5 score (95% confidence interval (CI)) was −23.7 (−26.94, −20.44) for MDMA-AT versus −14.8 (−18.28, −11.28) for placebo with therapy (P < 0.001, d = 0.7).

The placebo group got better, too! What this means is that therapy for PTSD actually works! It just works better on average with MDMA assistance.

it could be anything in any interval or nothing

we have FDA approved treatments that say “don’t do this for more than 2 years” and at the very least we can make objective choices because the side effects are listed… because those also occurred to an actual human being in a controlled environment

I can’t advocate for ignorance like this

And I couldnt find exact information about dosage and regularity in the paper...

Get some 5HTP in you.

Intuitively, this makes a lot of sense. MDMA is a fun drug because of the fact that it makes it basically impossible to feel negative emotion under its effect. PTSD is characterized by extreme negative emotion around a particular trauma, to such an extent that it becomes disruptive to living a normal life. Just talking about the traumatic inducing experience can lead to uncontrolled emotional responses, making it difficult to approach therapeutically. The MDMA acts as a shortcut around that last bit: by blocking the patient from feeling negative emotion while they talk about their trauma, they can re-evaluate it in a more removed way.

Combine that with theories about how we edit memories when we recall them, and you've got a pretty obvious method of action.

It's not intended to be a chronically taken treatment. But the results were pretty massive. That CAPS-5 score they talk about the reduction by 24 points versus therapy alone's 15 is on an 80 point scale, with the bare minimum for PTSD diagnosis at a 12, and "moderate" PTSD being in the 23-35 range.

Compared to most results coming out of the mental illness treatment field, MDMA's looking like a silver bullet.

There are multiple psychologist in my family, so maybe thats why im opposed to doing therapy with drugs unless physically necesarry.

Data disagrees with you.

I have seen tremendous improvement in quality of life of veterans with PTSD with just a few MDMA assisted therapy sessions.

If it really is just a few sessions with enough time between then im ok with that.

But there should be enough scientific evidence that anything more is very dangerous.

By all means, go find it and report back!

Wasnt that hard right. All just anecdotal evidence of course /S