There's probably a decent joke buried in the fact the first two they always talk about are the EPA and Education.

Libcom is the dominant viewpoint among those who advocate the admittedly fringe view of abolishing govt. Commenter was bewildered by the suggestion as though that’s the entirety of thought behind the idea in isolation

There are three main meanings:

1) "New Deal agencies"

2) "Since the 1990s, the term "alphabet agencies" has been commonly used to describe the agencies of the U.S. national security state."

3) Any government agency or cabinet department known by its initialism.

From context, #2 seems the most likely.

If #3, no more NASA. No more FAA. No more NOAA.