Unless you are extremely experienced with Factorio and want a challenge that will last you close to another 1,000 hours (at least) ... don't even attempt Pyanodons.

It's for a very specific type of hardcore player and very few people have actually finished it.

This is the flowchart for ONE science (space) ... one. There are numerous sciences.

https://i.imgur.com/JCVVTjn.jpg