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Re:Brandon Gilles Dies from Long-Covid, Electrical Engineer ... by haldujai on Tuesday August 15, 2023 @01:37AM (#37130579)
Brandon describes slowly improving over ~1.5 years up to April 2023 when he was walking ~0.9 miles/day which so far is concordant with ME/CFS but where it gets discordant is that he progressed to multi-organ failure and death within 3 months.

I'm not questioning whether he suffered from ME/CFS but mortality is not reported in the Stanford data or what I've heard described of the syndrome.

It's hard to wrap my head around ME/CFS as he has described it being causative of organ failure. Did something happen? Is this a consequence of the therapeutic he tried?

Organ failure in a 37 year old without a history of end-organ dysfunction or acutely inciting event like a toxicity is incredibly unusual.

Re:Brandon Gilles Dies from Long-Covid, Electrical Engineer ... by quenched on Wednesday August 16, 2023 @06:32AM (#37145069)
I agree it's hard to speculate: perhaps malnutrition and cardiac failure; maybe sepsis. Here are some relevant links —

Life-Threatening Malnutrition in Very Severe ME/CFS (2021)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070213/

Caring for the Patient with Severe or Very Severe Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (2021)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8544443/

There are not many mortality studies and few ME patients have had comprehensive autopsies —

Mortality in patients with myalgic encephalomyelitis and chronic fatigue syndrome (2016)

https://www.tandfonline.com/doi/full/10.1080/21641846.2016.1...

Causes of Death Among Patients With Chronic Fatigue Syndrome (2007)

https://www.tandfonline.com/doi/abs/10.1080/0739933060080376...

Somewhat harrowing reading is Whitney Dafoe's account of becoming extremely severe —

Extremely Severe ME/CFS—A Personal Account (2021)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8145314/