I will say as a nixos newbie coming from arch linux, I am seeing a lot of overlap between different functions and I'm probably not reading the docs carefully enough but I'm still sorting out the differences between nix-env, profiles, and this "home" thing which I still haven't figured out.

I get nix-shell though lol.

Probably not worth switching to guix just yet so long as I can get my emacs and cuda environment up and running.