Re:Reimagining the Bioreactor
by ggm on Wednesday August 09, 2023 @01:04AM
(#37058900)
Hate to use wikipedia as the source, but it states:
The production of butanol by biological means was first performed by Louis Pasteur in 1861.[5] In 1905, Austrian biochemist Franz Schardinger found that acetone could similarly be produced.[5] In 1910 Auguste Fernbach (1860–1939) developed a bacterial fermentation process using potato starch as a feedstock in the production of butanol.[6]
Methanol, Ethanol and Acetic acid (vinegar) production probably were the only precursor methods of bio reactor well understood.
Penicillin which was significant in WW22 was industrialised at scale by Du Pont and the USDA in Peoria using bioreactors. the British method (Ernest Chain Howard Florey), demanded huge surface area mould growing, in semi-open trays based on bedpans, which is what they jury-rigged in the lab for the first production cycles. du Pont took it and ran with it.
Leonard Bickel's biography of Florey has quite a lot about the industrialisation of production in bioreactors.
If you want another good story about them, read up on Quorn, and why it was invented and how Fusarium was bred up in bioreactors to try and make protein at scale. It was Lord Rank (the naked man banging the gong at the front of movies... No thats not Lord Rank, (it was his movie company) but it should be) who pushed for this, concerned about Soylent-green futures
The production of butanol by biological means was first performed by Louis Pasteur in 1861.[5] In 1905, Austrian biochemist Franz Schardinger found that acetone could similarly be produced.[5] In 1910 Auguste Fernbach (1860–1939) developed a bacterial fermentation process using potato starch as a feedstock in the production of butanol.[6]
https://en.wikipedia.org/wiki/Acetone%E2%80%93butanol%E2%80%...
Methanol, Ethanol and Acetic acid (vinegar) production probably were the only precursor methods of bio reactor well understood.
Penicillin which was significant in WW22 was industrialised at scale by Du Pont and the USDA in Peoria using bioreactors. the British method (Ernest Chain Howard Florey), demanded huge surface area mould growing, in semi-open trays based on bedpans, which is what they jury-rigged in the lab for the first production cycles. du Pont took it and ran with it.
Leonard Bickel's biography of Florey has quite a lot about the industrialisation of production in bioreactors.
If you want another good story about them, read up on Quorn, and why it was invented and how Fusarium was bred up in bioreactors to try and make protein at scale. It was Lord Rank (the naked man banging the gong at the front of movies... No thats not Lord Rank, (it was his movie company) but it should be) who pushed for this, concerned about Soylent-green futures
https://en.wikipedia.org/wiki/Quorn