You should look into MDFourier. "MDFourier is an open source software solution created to compare audio signatures and generate a series of graphs that show how they differ." The Genesis was one of the primary targets for this software, and for that reason I believe that Genesis sound emulation is very accurate.

https://junkerhq.net/MDFourier/

Genesis sound emulation is indeed tricky because there were multiple variants of the sound hardware in the Genesis over the years. Some emulators model multiple variants.

https://www.reddit.com/r/emulation/comments/104tgvs/sega_gen...