I've been using AdGuard and haven't seen a single ad since I installed it. AdGuard seems to offer a much of the same functionality from uBlock that I enjoyed, like being able to selectively block elements on the page, and choosing what filter lists I want. The only 'downside' is that I believe you have to pay for it, but I believe there is a free version that I use on my mother's MacBook.

AdGuard also offers a pi-hole-esque ad-blackhole that I deploy on my home network and it's got much better UX than pi-hole.