I do a lot of scientific computing in Python and have had awful experiences with Python 3. We encourage everyone who comes into our lab to work with 2.7 because the libraries are all there. It's true that Numpy and Scipy now build for Python 3, but another key library, PIL, is lost in limbo with no clear timeline for porting last I checked.

The only reason I've used Python 3 at all was because of project involving blender. I needed to do in-memory JPEG compression for quickly streaming images from the game engine. In Python 2, this is a couple lines of code using PIL. Instead, I ended up having to write my own pyjpeg module that provided a ctypes interface to a custom libjpeg-based compression library. I'm proud of the result, but the aggravation and frustration that entailed has removed any desire I have to move to Python 3.