Not that I agree with GP, but:

Isaac Newton? Brian Josephson, certainly. Francis Crick. Werner Forssmann. Marie and Pierre Curie, the way they kept on working even when dying from radiation poisoning. Tycho Brahe (with the partying and the drunken pet elk). Pythagoras. Probably Paul Erdosz? And a good number of the people working on energetic materials research.

In what sense were any of them nut jobs? All of these were traditionally pedigreed scientists, doing groundbreaking research at their institutions, under their own names. I'm asking for a historical parallel of a researcher who published an earth-shattering result anonymously, from their home lab, in a field unrelated to their day job, on a random night off chilling and watching movies?

Ah, sorry for misunderstanding. I was thinking of traditional scientists who turned out to be partially crazy. The context here should have made me catch your logic better.