Lots. I think one of the only arguments that needs to be made against things like gain-of-function research is this. [1] That's an incomprehensive list various announced biosecurity incidents.

Just since 2000 we've had lab incidents, including leaks, with: anthrax, west nile virus, SARS, COVID (not implying China - there was a confirmed COVID leak in Taiwan), ebola, tuberculosis, dengue, smallpox, zika, polio, and more. And they're happening all throughout the world. That includes the US, China, Russia, Japan, Germany, Australia, UK, South Korea, Hungary, France, Taiwan, Netherlands, and more. Incidents specified as coming from BSL-4 labs include ebola and SARS, though the BSL level is not specified at all for most incidents.

And I would take that is an extremely incomprehensive list given that many incidents are likely going to be tucked away or classified. There's playing with fire, and then there's this... which increasingly more feels like standing around a fire and seeing what happens if you start dumping kerosene into it, all in the name of firefighting - of course.

[1] - https://en.wikipedia.org/wiki/List_of_laboratory_biosecurity...