Interesting. My slight megalophobia sometimes gets aggravated in games, but never predictably. I still remember flying through the desert in GTA: San Andreas and having to veer away from approaching the giant radar telescope lest it cover too much of my field of view, or feeling on edge as the flying gryphon took me over the sparkling purple dome of Dalaran in World of Warcraft back when I played. Yet last year's Portal 2, full of massive domes, spheres, and doors, never came close to causing a problem.