Unfortunately, the link to the Wolfram talk on Feedburner isn't working. Here's a link to the transcript of the talk (the mp3 is also available for iPod-achievers by going to the talk index): http://www.stephenwolfram.com/publications/talks/ycombinator...

The talk is worth a read, but he doesn't give out any secrets to success ("work hard"), and note that the title of the talk is "On Starting a Long Term Company." It seems aimed at solving the problem of "How can I get the people, software, and money for my research?" rather than the problem of "How can I afford that ocean-front mansion and retire at 30?"