As long as you're not surprised by the dampening on your job prospects. I feel like there's a difference between not being a good fit, and not getting the opportunity to prove you're not a good fit. Some of your filter, as many are suggesting, is well before the interview process.

I'm mid-40s and have worked for myself since my late teens. I recently realised that I'm likely unemployable in a traditional office sense, and so will need to make everything work off my own back until retirement. Things are good now, but prospects and perceptions change quickly with age, depending on your field.