Second, they ferment fruit because fruit is always slightly poisonous (fructose).

Third, after being close to our primate relatives for some time, our ancestors spent a lot of time hunting, which is not a trait of monkeys we know. They eat more varied meat diet than any predator known, did that for a long time, much longer than (now) we eat crops.

Fourth, we have much higher normal percentage of fat in our body. For men, the normal fat percentage range is from 18% to 22%. Our primate relatives have much less normal fat, for most primates it is less than 9%. Our primate relatives sport bodybuilder's or high performance athlete's fat range just living their life.

As with alcohol, fructose is not a toxin in small doses, because liver can handle it (especially when it is fermented into lactic acid). But it is a toxin in doses we usually experience now. Look for "non-alcoholic fat liver syndrome".

But in general it's a far more complicated causality chain. When weight gain leads to insulin resistance then sugar is poison. We have lifestyles that maximize both a lack of physical labor and an excess of high sugar foods.

https://anthonycolpo.com/sweet-stupidity-part-2-the-bitter-t...

His understanding of what happens to fructose in the liver is fundamentally incorrect.

The way I understand it, poison is an umbrella term that includes toxins, venoms, and chemicals. Its definition is basically "is harmful to living beings", while the other three are specific types/sources of harmful.

Edit: Ended up looking it up, looks like I got poison and toxin backwards. Toxin is the umbrella term.