It's the potency and accessibility of drugs, now you can get fentanyl or meth that are dozens of times more pure and cheaper and available all over with virtually zero consequences. If you want to use drugs, there are no cops or doctors who are going to intervene and your family can't just force you into rehab. This new reality is simply sum of the cumulative bad decisions we've made--get rid of mental institutions, make health care unaffordable, tie insurance to employment so mentally ill and drug addicts have a harder time getting access to treatment, the breakup of the nuclear family, more females working and less time to raise their kids, decriminalize drugs, decriminalize sleeping outside in public places, decriminalize theft... this is the end result.