I am learning a new layout that does not have xcv in the same place but I fix this by using a layer that keeps the same positions for xcv when holding down cmd/ctrl
To be fair, I think that DVORAK is overkill. If you want a good compromise between ergonomics and ease of use, definitely go for Colemak. Also a way better choice if you are European, and occasionally need some accents or characters that are not on the Dvorak keyboard. If you are crazy about min-maxing every aspect of your typing, IMO it becomes a rabbit hole: programmer's dvorak, colemak DH and other mods etc. etc. Don't forget that the more your setup is away from the standards, the more it can be a pain to go back to the standard, or have other people use your setup
Used Dvorak (with some modifications for Estonian language) for few years around 2005. Then switched back to QWERTY as this is available on almost every computer. Was hard to switch back, but got used to it again in a week. Based on this experience I think alternative layouts are a bit overrated.
One bonus of Colemak is that it has the same location for the keys XCV used for cut, copy, and paste.