I think that's right, but ultimately all explanations we have are based on prior knowledge that is itself not necessarily complete. It's explanations all the way down, until we hit some primary observations or axiomatic assumptions that are the hardest to get rid of.

"Enlightened" was my bad choice of a word. I get overexcited when I think of how much we have learned in the past couple thousand years and I forget that we mainly learned how little we know. Or can explain!