The Running Is BS podcast is sponsored by a tea company: irrelevant to me as I don't drink tea at all (there is some relevance to the people making the cast, which is how the segment came about initially), hitting skip-forward-30s a couple of times each fortnight is no hardship to me. I listen enough that I perhaps should consider doing the Patreon thing, the fact that I and no doubt many others in a similar position don't do the Patreon thing is why the sponsor segment is useful to the creators.
The difference is that something new and potentially useful doesn't get skipped and it would automatically with sponsorblock. Hitting the right arrow key a couple of times is hardly a hardship. Before the sponsor segments on a video channel or podcast get to the point of irritation where I'd use something like sposorblock, I'll probably just start avoiding looking at that channel at all.
Sounds like the requirements would be: 1) it plays every new sponsorship pitch once, which you can still manually skip, and 2) it maybe asks you whether you want to skip on a per-instance level?
Perhaps once in a specified amount of time. Every two weeks? Sometimes I forget things and a reminder isn't inappropriate. Spread over all channels if possible, rather than once per channel per period.
Also rather than silently skipping, perhaps a couple of seconds pause with “sponsor segment for <product> skipped” displayed, at least as a default the individual users can switch off.
Here's a thought experiment, though: if you manually skip sponsor segments every single time you watch a video by dragging the scrubber, is that any different from having a piece of software do as much for you, in an automated fashion?