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Re:Design and synthesis of a minimal bacterial genome by XorNot on Friday July 07, 2023 @03:39AM (#36628485)
Makes you wonder if there's a possible set of RNA enzymes which could be isolated exist would be able to bootstrap the cytoplasmic environment as well.

The ultimate experiment would obviously be to go from a surfactant micelle in an amino acid soup to a functional cell synthesizing proteins using just genetic code or code precursors.

Re:Design and synthesis of a minimal bacterial genome by samus on Friday July 07, 2023 @06:41AM (#36629776)
That experiment probably can't be run end-to-end because evolution took an enormous time to cook up our biochemistry from the primordial soup. I could also be completely wrong, and we learn that simplistic cells can arise on short timescales if there is no competition from existing life.
Re:Design and synthesis of a minimal bacterial genome by XorNot on Friday July 07, 2023 @11:08AM (#36632886)
My thought was that if you just intentionally dumped the working components into the relevant areas, you would get a cell in short order - i.e. there's a combination of RNAzymes which must've existed on the transition from RNA-world to proteins, to DNA coding.

Basically: evolution trial and error'd, but it stands to reason that we could just sit there injecting the next step which worked each time.