Devuan and Synology come to mind. Devuan's kernels lead to segfaults that I didn't successfully diagnose. Synology's are missing some obscure system call that non-obsolete OpenSSL needs.

SmartOS (an Illumnos / solaris variant) is also a bit flaky, though was more stable than those two the last time I checked.

edit: Also, switching between RHEL and Ubuntu sometimes leads to VDSO mismatches, which can cause severe performance regressions. I've seen that with and without containers.