Without specifics about what its you're talking about, I have no idea what you're talking about.
What do you understand as Lisp? Does it include Clojure, Janet or Hy?
Every project has its unique struggles.
The adoption of absolutely everything outside of some half dozen popular things is virtually nonexistent. It has nothing to do with their syntax, because the field is full of wannabes striving for popularity of their project, by means of deliberately imitating the syntax of what is popular. It's not working; they're only ruining their project with garbage ideas for nothing.
Most of what is not popular is non-Lisp. Making a non-Lisp is as good a path to unpopularity as making a Lisp.
Some Lisp-likes are integrated into popular run-times and can use their ecosystems. Robustness of the ecosystem is obviously a non-issue for them. They can be used gradually; like a few files of some project written in another language can be in the Lisp-like. That counts as a valid use.
However, despite the ongoing development and evolution of Lisp, it seems that its adoption in commercial settings may still be limited due to factors such as maintainability, developer availability, and the robustness of language ecosystems. I’d be interested to hear your thoughts on how these factors might be addressed to increase Lisp’s adoption in these environments.
I also agree that those who are knowledgeable in both Lisp and other programming languages likely make better-informed decisions regarding language choice. In your experience, how do these programmers navigate the choice between Lisp and more mainstream languages in different scenarios? I look forward to your insights.