How many jobs are you applying for? It's harder when you're a graduate looking for a job. When you're senior you're probably only applying for a handful of roles that caught your eye and it only takes 10 minutes to refactor your CV to make it more relevant to each company.
As a senior, you have to apply for lots of jobs because most the jobs you apply for won't hit the requirements (for example, salary). For reference, I have 15+ years of experience so I'm fairly senior for the industry.
The last time I thought about getting a stable job I got quite a few interviews but most of them were offering £100 to £120k which I consider fairly low (I was making that in 2014...)
It's honestly quite a waste of time, I don't know how much different it is across the pond but I imagine it's easier over there, considering the kind of comments you read on HN and such
I got flooded with job spam that way. As a signal-to-noise ratio, I would much rather strip all the keywords from my CV and get an occasional cold call (or e-mail) than wake up every day to a mailbox full of jobs that are not related to what I've done, but matched some keyword on my resume.
I never tailored the cv to each job as that would take way too much time, especially as you get more senior. As a junior developer, sure, it might be worth it because you might get offers from most jobs you apply for. Nowadays I would have to apply for dozens of jobs to find a good fit.
This might only apply for EU and UK though, I imagine things are a lot better in the US