> mapping PCIE as Device-nGnRE

Disclaimer: completely unaware of what that means.

Does it preclude such a card working _at all_ or can it still be used e.g for e.g CUDA?

Would it be possible for e.g Nvidia to create a special batch of cards or design that would work for such cases? (priced through the roof given the small user base but that'd also be the kind of user base who would drop stupid amounts of money without batting an eye)

Considering nVidia has the Grace CPU and probably a significant investment in arm64 development, I'd say yes absolutely. If anyone could do it it's them. Of course theres probably a better chance of Atlantis rising from the sea.