> If your lungs can’t breathe well, doctors can put you on a ventilator, which forces air in and out. It’s hard to get ventilators working right. Sometimes they push in too much air and injure your lungs. Sometimes they push in too little air and you suffocate. There are big fights about what settings to run ventilators on for which patients. For a while, doctors fought over whether to set ventilators on high vs. low, with many experts in each camp. Researchers formed a consortium called PETAL to study this.
Then, an institutional review board blocked the study:
> Its director, ethicist Jerry Menikoff, had decided maybe it was unethical to do RCTs on ventilator settings at all. He asked whether they might be able to give every patient the right setting while still doing the study. The study team tried to explain to him that they didn’t know which was the right setting, that was why they had to do the study. He wouldn’t budge.
Yes, putting someone on the wrong ventilator setting could kill them! That's obviously evil! Unfortunately, nobody knew which setting was the wrong one! The only way to find out was to try both, in a systematic and scientifically-valid fashion.
https://astralcodexten.substack.com/p/book-review-from-overs...
> If your lungs can’t breathe well, doctors can put you on a ventilator, which forces air in and out. It’s hard to get ventilators working right. Sometimes they push in too much air and injure your lungs. Sometimes they push in too little air and you suffocate. There are big fights about what settings to run ventilators on for which patients. For a while, doctors fought over whether to set ventilators on high vs. low, with many experts in each camp. Researchers formed a consortium called PETAL to study this.
Then, an institutional review board blocked the study:
> Its director, ethicist Jerry Menikoff, had decided maybe it was unethical to do RCTs on ventilator settings at all. He asked whether they might be able to give every patient the right setting while still doing the study. The study team tried to explain to him that they didn’t know which was the right setting, that was why they had to do the study. He wouldn’t budge.
Yes, putting someone on the wrong ventilator setting could kill them! That's obviously evil! Unfortunately, nobody knew which setting was the wrong one! The only way to find out was to try both, in a systematic and scientifically-valid fashion.