Synthesised, and natural. The growth in popularity for micro-dosing mushrooms and cannabis speaks for itself, and have weaned many off the really bad 'quaaludes', and also off the really bad, but ' considered lighter' Xannies and other benzo's. "Made in a factory, or something that grows?", is a big factor in how people approach their ingestion. I do enjoy, the mathematical difference between manufactured lsd and natural shrooms, though.