I had to go on TRT about six years ago because of brain tumor (prolactinoma) that effectively destroyed my ability to produce testosterone. My prescribing doctor was and is an endocrinologist, and he told me from the very beginning that there was no direct increased risk for cardiac events, but it does increase RBC, so hypertension becomes a risk, with all of the obvious negatives that comes with. If you’re on TRT or plan on doing it in the future, regularly check your BP. I believe regular blood tests is the standard protocol as well.

My experience is that I have a slightly better mood, BUT, I have increased libido that does a crazy spike about halfway through the cycle (where I feel a raging insatiable teenager), followed by a significant drop in both mood and libido. It’s rather annoying, but better than the alternative.