So it seems, but perhaps after a while they would get used to it and new constellations could evolve :-)

Likewise I wonder if the ISS was designed with specific sides for up and down in mind of if all sides are created equal. In the video some signs are visible which seem to be all aligned in the same direction, but what about tools and furniture?

There are different sections. Most is pragmatic, but the crew areas have a "down" to make the people feel better when they stay there.