I remember reading that the American Cancer Society is the richest non-profit organisation in the country and that the top X people are paid a LOT of money.
I don't care enough to look up citations to back that up though, if anyone is interested I'd suggest going on Google and looking into it for yourself.
In my own situation, which did involve TNT, I found myself rather skeptical, if not cynical, about the Big Cancer Research Establishment. I think it exists primarily as a self-preserving bureaucracy and does precious little actual research. (I could be wrong; I haven't really looked into it.) Under the circumstances, I nonetheless gave an amount which I thought was generous (and which was larger than $10). It was still received as inadequate. This did not dispose me to be generous with similar requests in the future.